Synthesis

Palladium-catalyzed cyanation reactions of thiophene halides

T Erker, S Nemec

Index: Erker, Thomas; Nemec, Stephanie Synthesis, 2004 , # 1 p. 23 - 25

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Citation Number: 5

Abstract

Abstract The described method provides an efficient cyanation reaction of thiophene halides using tris (dibenzylidene-acetone) dipalladium (0), 1, 1′-bis-(diphenylphosphino) ferrocene) and zinc powder as the catalyst system and Zn (CN) 2 as the cyanide source. Several thiophenes with various substituents are effectively cyanated under these conditions.