Synthesis and Biological Evaluation of the Geometric Farnesylated Analogues of the a-Factor Mating Peptide of Saccharomyces c erevisiae

H Xie, Y Shao, JM Becker, F Naider…

Index: Xie; Shao; Becker; Naider; Gibbs Journal of Organic Chemistry, 2000 , vol. 65, # 25 p. 8552 - 8563

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Citation Number: 39

Abstract

The a-factor of Saccharomyces cerevisiae is a dodecapeptide pheromone (YIIKGVFWDPAC (Farnesyl)-OCH3, 1), in which post-translational modification with a farnesyl isoprenoid and carboxymethyl group is required for full biological activity. This peptide has been used as a model system to explore the biological function of the farnesylcysteine moiety, which is found on and required for the biological activity of many key mammalian proteins. The ...