Preparation of 3-substituted-2-pyridin-2-ylindoles: regioselectivity of Larock's indole annulation with 2-alkynylpyridines

…, J Liu, E Estanove, M Dufour, S Rodríguez, V Farina…

Index: Roschangar, Frank; Liu, Jianxiu; Estanove, Emilie; Dufour, Marine; Rodriguez, Sonia; Farina, Vittorio; Hickey, Eugene; Hossain, Azad; Jones, Paul-James; Lee, Heewon; Lu, Bruce Z.; Varsolona, Richard; Schroeder, Juergen; Beaulieu, Pierre; Gillard, James; Senanayake, Chris H. Tetrahedron Letters, 2008 , vol. 49, # 2 p. 363 - 366

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Citation Number: 20

Abstract

A regioselective Larock approach to 3-substituted-2-pyridin-2-ylindoles from 2- alkynylpyridines and 2-iodoanilines is described herein. The unexpectedly high regioselectivity can be rationalized by a combination of steric, coordinative and electronic effects.