2-(1-Methyl-1, 2, 5, 6-tetrahydropyridin-3-yl) morpholine is useful for synthesizing potent antimicrobials including the arecoline derivatives, phendimetrazine and polygonapholine and was synthesised in nine steps with an overall yield of 36%. Bromination of 3- acetylpyridine and dehydration of a diol with cyclization were pivotal to the success of the strategy.
