Synthesis, characterization and antiproliferative activity of β-aryl-δ-iodo-γ-lactones

…, W Gładkowski, M Urbaniak, A Barańska…

Index: Wzorek, Alicja; Gawdzik, Barbara; Gladkowski, Witold; Urbaniak, Mariusz; Baranska, Anita; Malinska, Maura; Wozniak, Krzysztof; Kempinska, Katarzyna; Wietrzyk, Joanna Journal of Molecular Structure, 2013 , vol. 1047, p. 160 - 168

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Citation Number: 6

Abstract

A convenient pathway for the synthesis of new of β-aryl-δ-iodo-γ-lactones is described. The synthetic route led to both cis and trans isomers which were separated by column chromatography or crystallization. The structures of synthesized compounds were confirmed by spectroscopic methods: IR, NMR and HR-MS. For lactones with naphthyl ring (6e and 7e) the crystal structures were also obtained. The lactones were screened for biological ...