Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents—synthesis, antiproliferative activity and inhibition of tubulin polymerization

…, P Schmidt, KJ Böhm, S Baasner, K Müller…

Index: Prinz, Helge; Schmidt, Peter; Boehm, Konrad J.; Baasner, Silke; Mueller, Klaus; Gerlach, Matthias; Guenther, Eckhard G.; Unger, Eberhard Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 14 p. 4183 - 4191

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Citation Number: 7

Abstract

Abstract A novel series of phenylimino-10H-anthracen-9-ones and 9-(phenylhydrazone)-9, 10-anthracenediones were synthesized and evaluated for interaction with tubulin and for cytotoxicity against a panel of human tumor cell lines. The 10-(3-hydroxy-4-methoxy- phenylimino)-10H-anthracen-9-one 15h and its dichloro analog 16b were identified as potent inhibitors of tumor cell growth (16b, IC 50 K562 0.11 μM), including multidrug ...