e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1, 3, 8-triazaspiro [4.5] decan-8-yl) ethyl) benzamides: discovery of an isoform- …
…, PE Selvy, K Kim, S Jadhav, RD Morrison…
Index: Lavieri, Robert R.; Scott, Sarah A.; Selvy, Paige E.; Kim, Kwangho; Jadhav, Satyawan; Morrison, Ryan D.; Daniels, J. Scott; Brown, H. Alex; Lindsley, Craig W. Journal of Medicinal Chemistry, 2010 , vol. 53, # 18 p. 6706 - 6719
Phospholipase D (PLD) catalyzes the conversion of phosphatidylcholine to the lipid second messenger phosphatidic acid. Two mammalian isoforms of PLD have been identified, PLD1 and PLD2, which share 53% sequence identity and are subject to different regulatory mechanisms. Inhibition of PLD enzymatic activity leads to increased cancer cell apoptosis, decreased cancer cell invasion, and decreased metastasis of cancer cells; therefore, the ...
![8-benzyl-1-(4-fluorophenyl)-1,3,8-triazaspiro[4,5]decan-4-one Structure](https://image.chemsrc.com/caspic/179/85098-78-8.png)
![1-(4-fluorophenyl)-1,3,8-triazaspiro[4,5]decan-4-one Structure](https://image.chemsrc.com/caspic/164/58012-16-1.png)
![8-benzyl-1-(4-fluorophenyl)-1,3,8-triazaspiro[4.5]dec-2-en-4-one Structure](https://image.chemsrc.com/caspic/266/167263-29-8.png)
![8-Benzyl-1-(4-chlorophenyl)-1,3,8-triazaspiro[4.5]decan-4-one Structure](https://image.chemsrc.com/caspic/218/976-96-5.png)
![1-(4-chlorophenyl)- 1,3,8-triazaspiro[4.5]decan-4-one Structure](https://image.chemsrc.com/caspic/148/61271-84-9.png)
![8-Benzyl-1-(4-bromophenyl)-1,3,8-triazaspiro[4.5]decan-4-one Structure](https://image.chemsrc.com/caspic/091/1244639-67-5.png)
![1-(4-bromophenyl)-1,3,8-triazaspiro[4.5]decan-4-one Structure](https://image.chemsrc.com/caspic/262/61271-81-6.png)