Synthesis, biological activity and structure–activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic …

R Ottanà, R Maccari, J Mortier, A Caselli…

Index: Ottana, Rosaria; Maccari, Rosanna; Mortier, Jeremie; Caselli, Anna; Amuso, Simona; Camici, Guido; Rotondo, Archimede; Wolber, Gerhard; Paoli, Paolo European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 112 - 127

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Citation Number: 12

Abstract

Abstract Insulin resistance is a complex altered metabolic condition characterized by impaired insulin signaling and implicated in the pathogenesis of serious human diseases, such as diabetes, obesity, neurodegenerative pathologies. In pursuing our aim to identify new agents able to improve cellular insulin sensitivity, we have synthesized new 4-[(5- arylidene-4-oxo-2-phenylimino/oxothiazolidin-3-yl) methyl] benzoic acids (5, 8) and ...