Chemical and pharmaceutical bulletin

Cleavage of SS Bond by Nitric Oxide (NO) in the Presence of Oxygen. A Disproportionation Reaction of Two Disulfides.

N Tsutsumi, T Itoh, A Ohsawa

Index: Tsutsumi; Itoh; Ohsawa Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 10 p. 1524 - 1528

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Citation Number: 7

Abstract

Disulfide bond was cleaved by a catalytic amount of nitric oxide in the presence of oxyge, which was confirmed by experiments employing two symmetrical disulfides. The reaction resulted in the formation of unsym-metrical disulfides in nearly 50% yields. The steric