Fluoro-substituted and 13 C-labeled styrylbenzene derivatives for detecting brain amyloid plaques

…, M Higuchi, N Iwata, TC Saido, K Sasamoto

Index: Sato, Kumi; Higuchi, Makoto; Iwata, Nobuhisa; Saido, Takaomi C.; Sasamoto, Kazumi European Journal of Medicinal Chemistry, 2004 , vol. 39, # 7 p. 573 - 578

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Citation Number: 65

Abstract

Two styrylbenzene derivatives,(E, E)-1-fluoro-2, 5-bis-(3-hydroxycarbonyl-4-hydroxy) styrylbenzene (FSB) and (E, E)-1-bromo-2, 5-bis (3-hydroxycarbonyl-4-hydroxy) styrylbenzene-α, α′-13C2 ([13C] BSB), were synthesized for use as a histochemical stain to detect amyloid plaques of Alzheimer's disease (AD) brain sections. An analysis of fluorescence spectra demonstrated that FSB shows approximately twofold fluorescence ...