Optically active iridium imidazol-2-ylidene-oxazoline complexes: preparation and use in asymmetric hydrogenation of arylalkenes

…, DR Hou, JH Reibenspies, K Burgess

Index: Perry, Marc C.; Cui, Xiuhua; Powell, Mark T.; Hou, Duen-Ren; Reibenspies, Joseph H.; Burgess, Kevin Journal of the American Chemical Society, 2003 , vol. 125, # 1 p. 113 - 123

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Citation Number: 385

Abstract

This work explores the potential of iridium complexes of the N-heterocyclic carbene oxazoline ligands 1 in asymmetric hydrogenations of arylalkenes. The accessible carbene precursors, imidazolium salts 2, and robust iridium complexes 5 facilitated a discovery/optimization approach that featured preparation of a small library of iridium complexes, parallel hydrogenation reactions, and automated analysis. Three of the ...