Archives of pharmacal research

Design and synthesis of some new quinazolin-4-(3H)-ones as anticonvulsant and antidepressant agents

M Amir, I Ali, MZ Hassan

Index: Amir, Mohd; Ali, Israr; Hassan, Mohd Zaheen Archives of Pharmacal Research, 2013 , vol. 36, # 1 p. 61 - 68

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Citation Number: 9

Abstract

Abstract A series of 3-[(4-substituted-benzylidene)-amino]-2-phenyl-3 H-quinazolin-4-ones (5a–k) were synthesized by reacting 3-amino-2-phenyl-1 H-quinazolin-4-one with p- hydroxybenzaldehyde, and then further with various alkyl/benzyl halides or substituted phenacyl bromides. The structures of the compounds were confirmed on the basis of IR, NMR, MS and elemental analysis. Anticonvulsant activities were evaluated using the MES ...