e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Effect of 6-aminonicotinamide and other protein synthesis inhibitors on formation of platinum-DNA adducts and cisplatin sensitivity
II Budihardjo, SA Boerner, S Eckdahl, PA Svingen…
Index: Budihardjo, I. Imawati; Boerner, Scott A.; Eckdahl, Steven; Svingen, Phyllis A.; Rios, Robert; Ames, Matthew M.; Kaufmann, Scott H. Molecular Pharmacology, 2000 , vol. 57, # 3 p. 529 - 538
Abstract The present study was undertaken to examine the mechanistic basis for the recent observation that the pyridine nucleotide derivative 6-aminonicotinamide (6AN, NSC 21206) enhances the accumulation and resulting cytotoxicity of cisplatin in a variety of tumor cell lines. When A549 lung cancer cells or K562 leukemia cells were treated with 62.5 μM 6AN for 21 h and then pulse-labeled with [35 S] methionine for 1 h, increased labeling of five ...
