Abstract A series of a novel hybrid compounds between nitazoxanide and N- methylbenzimidazole were synthesized starting from the corresponding N-methyl-2- nitroanilines. The new hybrid compounds (1–13) were evaluated in vitro against Giardia intestinalis, Entamoeba histolytica, Trichomonas vaginalis. NTZ, MTZ and ABZ were used as drug standards. Experimental evaluations revealed all of the new compounds (1–13) were ...