Chemical Communications

Cobalt-catalysed hydrovinylation as the key step in a short synthesis of moenocinol

G Hilt, J Treutwein

Index: Hilt, Gerhard; Treutwein, Jonas Chemical Communications, 2009 , # 11 p. 1395 - 1397

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Abstract

The disconnection of the right-hand-side part of 1 could be accomplished by an olefination reaction utilising the sulfone3via a Julia–Kocienski reaction with the corresponding aldehyde of 2. 7 Firstly, we addressed the synthesis of the right-hand-side part 3, which can be easily accomplished by a three-step synthesis starting from commercially available 5-chloropentan-2-one (5) and 1-phenyl-1H-tetrazol-5-thiole (PT-SH). The substitution and the subsequent oxidation of ...