Synthetic Communications

LiClO4-Accelerated Three-Component Mannich-Type Reaction of Diethyl Malonate with Imines: An Efficient Synthesis of β-Amino Esters Under Solvent-Free …

F Aryanasab, MR Saidi

Index: Aryanasab, Fezzeh; Saidi, Mohammad R. Synthetic Communications, 2008 , vol. 38, # 22 p. 4036 - 4044

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Citation Number: 7

Abstract

Abstract LiClO4 is used as catalyst for direct Mannich-type reaction of aryl aldehydes, aryl amines, and diethyl malonic ester under solvent-free conditions. This three-component reaction afforded the corresponding β-amino esters in good yields with simple and environmentally benign procedure.