Spirocyclic nonpeptide glycoprotein IIb–IIIa antagonists. Part 1: design of potent and specific 3, 9-diazaspiro [5.5] undecanes

…, T Schotten, J Seroogy, D Volkots, A Pandey…

Index: Smyth; Rose; Mehrotra; Heath; Ruhter; Schotten; Seroogy; Volkots; Pandey; Scarborough Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 10 p. 1289 - 1292

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Citation Number: 18

Abstract

The synthesis and biological activity of novel glycoprotein IIb–IIIa antagonists containing the 3, 9-diazaspiro [5.5] undecane nucleus are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of the spirocyclic structures as a central template for nonpeptide RGD mimics.