Abstract Pyrrolo [2, 3-d] thiazoles are conveniently derived from the corresponding o- aminoalkynylthiazoles via microwave assisted 5-endo-dig cyclization. Methylene-bridged substituents in the 6-position are directly obtained from 5-exo-Heck cyclization based on the same iodoaminothiazole precursor. Further structural variety is accessible via Suzuki reaction of 2-chloroaminothiazoles prior to cyclization or post-cyclization modifications.
![tert-butyl N-{5-[(triethylsilyl)ethynyl]-1,3-thiazol-4-yl}carbamate Structure](https://image.chemsrc.com/caspic/392/1258934-74-5.png)
![4H-PYRROLO[2,3-D]THIAZOLE Structure](https://image.chemsrc.com/caspic/155/298699-45-3.png)