Tetrahedron

Synthesis of novel 1-, 1, 4-and 1, 7-substituted 2-mercapto-and 2-methylmercapto-benzimidazoles: Acyclic analogues of the HIV-1 RT inhibitor, TIBO

JM Gardiner, CR Loyns

Index: Gardiner, John M.; Loyns, Colin R. Tetrahedron, 1995 , vol. 51, # 42 p. 11515 - 11530

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Citation Number: 18

Abstract

Synthetic approaches towards acyclic analogues of the HIV-1 RT inhibitor TIBO ring system, lacking either the diazepine C7 methylene, C5-N6 bond or the N1-N6 two-carbon bridge, are reported, utilizing ring opening reactions of 2-methylaziridines. A number of isomeric 2- methylmercaptobenzimidazole analogues have also been prepared, and the regiochemistry of 2-methylmercaptobenzimidazole alkylations is discussed, as a convenient route to 1, 2, ...