Abstract The synthesis of phospholipids 1 n–3 n, rationally designed for two-dimensional crystallization of progesterone and estradiol receptors, is reported. The structure of these lipids provides them with essential properties such as fluidity and stability when spread into monolayers at the air/H 2 O interface, affinity for the protein to be crystallized, and accessibility of the ligand under the lipid monolayer.
