1-Aryl-3-(2-chloroethyl) ureas: synthesis and in vitro assay as potential anticancer agents

RC Gaudreault, J Lacroix, M Pagé…

Index: Gaudreault; lacroix; Page; Joly Journal of Pharmaceutical Sciences, 1988 , vol. 77, # 2 p. 185 - 187

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Citation Number: 16

Abstract

Abstract 1-Aryl-3-(2-chloroethyl) ureas and 1-aryl-3-nitroso-3-(2-chloroethyl) ureas, derived from 4-phenylbutyric acid and alkylanilines, were synthesized and their cytotoxicity was evaluated on human adenocarcinoma cells in vitro. Methyl 4-[p-[3-(2-chloroethyl) ureido]- phenyl] butyrate, 4-methyl [3-(2-chloroethyl) ureido] benzene, and 4-butyl [3-(2-chloroethyl) ureido] benzene were found to be at least as cytotoxic as 4-[p-[bis-(2-chloroethyl) amino] ...