Pyridone derivatives as potent and selective VLA-4 integrin antagonists

J Witherington, V Bordas, A Gaiba, PM Green…

Index: Witherington, Jason; Bordas, Vincent; Gaiba, Alessandra; Green, Phil M.; Naylor, Antoinette; Parr, Nigel; Smith, David G.; Takle, Andrew K.; Ward, Robert W. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 8 p. 2256 - 2259

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Citation Number: 9

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A novel series of pyridone inhibitors has been identified through pharmacophore analysis, as potent antagonists of VLA-4. ... Employing molecular overlay studies of our initial leads with known VLA-4 antagonists has led to the hypothesis of a novel pharmacophore. Subsequent ...