Antiinflammatory phospholipase-A 2 inhibitors. I

W Wilkerson, I DeLucca, W Galbraith, K Gans…

Index: Wilkerson; DeLucca; Galbraith; Gans; Harris; Jaffee; Kerr European Journal of Medicinal Chemistry, 1991 , vol. 26, # 7 p. 667 - 676

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Citation Number: 43

Abstract

Abstract A novel series of dehydroabietylamine derivatives has been synthesized and shown to be inhibitors of phospholipase-A 2 (PLA 2). These compounds exhibit in vivo antiinflammatory activity in the rat carrageenan paw edema assay and support the concept of PLA 2 inhibition as an approach to the discovery of novel antiinflammatories.