Synthesis of 2-phenylthiazolidine derivatives as cardiotonic agents. II. 2-(Phenylpiperazinoalkoxyphenyl) thiazolidine-3-thiocarboxamides and the corresponding …

…, K MATSUKI, A TSUNASHIMA, H OHTSUKA…

Index: Nate; Matsuki; Tsunashima; Ohtsuka; Sekine; Oda; Honma; Ishida; Nakai; Wada Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 6 p. 2394 - 2411

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Citation Number: 12

Abstract

A large number of 2-(phenylpiperazinoalkoxyphenyl) thiazolidine-3-thiocarboxamides and the corresponding carboxamides (II) were synthesized and tested for inotropic activity in anesthetized dogs. Compounds II were prepared from a hydroxybenzaldehyde (III) through the intermediates (IV, V, and X). Structure-activity relationships (SAR) were investigated by varying the structural parameters. Transposition of the piperazinoalkoxyl group to the meta ...