Tetrahedron

An efficient synthesis of JSTX-3, a potent neurotoxin of Joro spider (Nephila clavata)

M Matsushita, T Kanemura, S Hatakeyama, H Irie…

Index: Matsushita, Masayuki; Kanemura, Takanori; Hatakeyama, Susumi; Irie, Hiroshi; Toki, Takashi; Miyashita, Masaaki Tetrahedron, 1995 , vol. 51, # 39 p. 10687 - 10698

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Citation Number: 12

Abstract

JSTX-3 (Joro spider toxin-3)(1), a potent neurotoxin isolated from Joro spider (Nephila clavata), has been efficiently synthesized starting from 5-azido-lN-Boc-pentylamine (11) via the convergent synthetic strategy in which the characteristic polyamine components of the toxin were effectively constructed by the use of two key azide intermediates.

Synthesis of spider toxin (JSTX-3) and its analogs

[Hashimoto, Yuichi; Endo, Yasuyuki; Shudo, Koichi; Aramaki, Yoshio; Kawai, Nobufumi; Nakajima, Terumi Tetrahedron Letters, 1987 , vol. 28, # 30 p. 3511 - 3514]

Selective endothelin A receptor ligands. 1. Discovery and st...

[Astles; Brown; Handscombe; Harper; Harris; Lewis; Lockey; McCarthy; McLay; Porter; Roach; Smith; Walsh European Journal of Medicinal Chemistry, 1997 , vol. 32, # 5 p. 409 - 423]