It was reported that amides of isonicotinic [1, 2], 2-chloroisonicotinic [3], 2-chlorocinchoninic [5, 6], and 2-oxocinchoninic [7, 8] acids possess antiinflammatory properties. In continuation of the previous investigations aimed at finding new effective antiinflammatory agents, we have synthesized a series of previously unreported substituted amides and esters of 2- chloroisonicotinic acid (Ia–Ij, Table 1) and aryl esters of 2-chloro-(IIa–IIg) and 2- ...
