Introduction. L-Glutamic acid (LG~ u) is the major neurotransmitter at excitatory synapses in the central nervous system (CNS) and is considered to be involved in events leading to neuronal plasticity and in those involved in neuronal death. 1, 2 Synaptically released LG~ u acts on ionotropic and metabotropic classes of excitatory amino acid (EAA) glutamate receptors. Ionotropic EAA receptors belong to the ligand-gated ion channels superfamily, ...
