European Journal of Organic Chemistry

Microwave??Assisted Catalytic Intermolecular Hydroamination of Alkynes

I Bytschkov, S Doye

Index: Bytschkov, Igor; Doye, Sven European Journal of Organic Chemistry, 2001 , # 23 p. 4411 - 4418

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Citation Number: 51

Abstract

Abstract Irradiation of reaction mixtures containing an alkyne, an amine, and a catalytic amount of Cp 2 TiMe 2 in toluene with microwaves at a frequency of 2.45 GHz and a power output of 180− 300 W results in fast reactions to give the corresponding hydroamination products. The initially formed imines can easily be reduced to secondary amines by use of H 2/Pd, LiAlH 4, or NaCNBH 3/p-TsOH. The microwave-assisted hydroamination reactions ...