Organic Letters

A novel route to pyrrolo [2, 1-c][1, 4] benzodiazepin-5-ones. Formal total synthesis of (±)-DC-81

T Wang, AS Lui, IS Cloudsdale

Index: Wang, Tiansheng; Lui, Alfred S.; Cloudsdale, Ian S. Organic Letters, 1999 , vol. 1, # 11 p. 1835 - 1837

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Citation Number: 47

Abstract

Currently there is considerable interest in the discovery and development of small molecules such as pyrrolo[2,1-c][1,4]benzodiazepines (PBD's) as potential antitumor and gene targeted drugs. 1 The PBD class of antitumor antibiotics exert their biological activity by covalently binding to the N-2 of guanine in the minor groove of DNA through the imine or imine equivalent functionality at N10−C11 of the PBD's. Anthramycin (1) and DC-81 (2) are two well-known and ...