Organic process research & development

Development of a continuous enzymatic process for the preparation of (R)-3-(4-fluorophenyl)-2-hydroxy propionic acid

J Tao, K McGee

Index: Tao, Junhua; McGee, Kevin Organic Process Research and Development, 2002 , vol. 6, # 4 p. 520 - 524

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Citation Number: 45

Abstract

While many methods have been reported for the synthesis of chiral 2-hydroxy acids, few of them have proven to be reliable toward the synthesis of the title compound in terms of overall yield and enantioselectivity. Herein we describe a continuous enzymatic process for an efficient synthesis of (R)-3-(4-fluorophenyl)-2-hydroxy propionic acid at multikilogram scale with a high space-time yield (560 g/(L⊙ d)) using a membrane reactor. The product ...