Tetrahedron

Synthesis of optically active alkynyl alcohols and α-hydroxy esters by microbial asymmetric hydrolysis of the corresponding acetates

K Mori, H Akao

Index: Mori, Kenji; Akao, Hiroko Tetrahedron, 1980 , vol. 36, # 1 p. 91 - 96

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Citation Number: 85

Abstract

Asymmetric hydrolysis of the acetates of racemic alkynyl alcohols and α-hydroxy esters by Bacillus subtilis var. Niger afforded optically active acetates and alcohols in 7–90% optical purities. The both enantiomers of optically pure mandelie acid were prepared by this microbial method.