Synthesis and antitumor activity of optically active thiourea and their 2-aminobenzothiazole derivatives: A novel class of anticancer agents

…, KV Parihar, SAM Reddy, V Ramani, AK Gadad…

Index: Manjula; Malleshappa Noolvi; Vipan Parihar; Manohara Reddy; Ramani, Vijay; Gadad, Andanappa K.; Singh, Gurdial; Gopalan Kutty; Mallikarjuna Rao European Journal of Medicinal Chemistry, 2009 , vol. 44, # 7 p. 2923 - 2929

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Citation Number: 87

Abstract

A novel series of optically active 2-aminobenzothiazole derivatives were synthesized by reaction of optically active amine (I) with thiophosgene to obtain optically active isothiocyanates (IIa–h) which on condensation with 4-fluoro-3-chloro aniline (III) yielded ...