Synthesis and Biophysical Studies on 35??Deoxy Amphotericin B Methyl Ester

…, JM Manthorpe, NR Wurtz, EM Carreira

Index: Szpilman, Alex M.; Cereghetti, Damiano M.; Manthorpe, Jeffrey M.; Wurtz, Nicholas R.; Carreira, Erick M. Chemistry - A European Journal, 2009 , vol. 15, # 29 p. 7117 - 7128

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Citation Number: 30

Abstract

Abstract The use of molecular editing in the elucidation of the mechanism of action of amphotericin B is presented. A modular strategy for the synthesis of amphotericin B and its designed analogues is developed, which relies on an efficient gram-scale synthesis of various subunits of amphotericin B. A novel method for the coupling of the mycosamine to the aglycone was identified. The implementation of the approach has enabled the ...