Enantioselective enzymatic aminolysis and ammonolysis of dimethyl 3-hydroxyglutarate. Synthesis of (R)-4-amino-3-hydroxybutanoic acid

S Puertas, F Rebolledo, V Gotor

Index: Puertas, Susana; Rebolledo, Francisca; Gotor, Vicente Journal of Organic Chemistry, 1996 , vol. 61, # 17 p. 6024 - 6027

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Citation Number: 48

Abstract

Enzymes are now widely recognized as practical catalysts for asymmetric synthesis, 1 their abilities to discriminate between enantiotopic groups or faces of a prochiral molecule being of particular importance. Hydrolysis, transesterification, or lactonization processes2 have been applied to prochiral diesters and diols in order to prepare chiral synthons of high optical purity. However, the potential of enzymes, especially lipases, to catalyze the ...