Synthesis of Filibuvir. Part III. Development of a Process for the Reductive Coupling of an Aldehyde and a β-Keto-lactone

…, J Blunt, K Meldrum, S Taylor, C Byrne…

Index: Jiang, Sheng; Li, Peng; Lai, Christopher C.; Kelley, James A.; Roller, Peter P. Journal of Organic Chemistry, 2006 , vol. 71, # 19 p. 7307 - 7314

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Abstract

... Organic Process Research ... In the previous two articles (Synthesis of Filibuvir, Parts I and II, the preceding two articles in this journal) we described two ... due to the temperatures required to establish equilibrium between the bis-adduct and Knoevenagel alkene (>60 °C). At these ...