Tetrahedron: Asymmetry

Saponaceolides: differential cytotoxicity and enantioselective synthesis of the right-hand lactone moiety

G Vidari, G Lanfranchi, P Sartori, S Serra

Index: Vidari; Lanfranchi; Sartori; Serra Tetrahedron Asymmetry, 1995 , vol. 6, # 12 p. 2977 - 2990

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Citation Number: 20

Abstract

The enantioselective synthesis of the right-hand lactone moiety 5 of saponaceolide B, 2, is described. The mean graph profiles of 5 do not match the characteristic patterns of differential cytotoxicity of saponaceolides A, 1, and B, 2, in the NCI human disease-oriented tumor screening panel, pointing out the need of the entire saponaceolide structure for maintaining the specificity and potency of the antitumor activity. En route to 5 several ...