A study of structure-activity relationships of a series of 'dipeptoid'CCK-B receptor antagonists was performed in which variations of the phenyl ring were examined while the [(2- adamantyloxy) carbonyl]-α-methyl-R)-tryptophan moiety of the potent antagonist CI-988 was kept constant. Since the main focus of this study was phenyl substituent variation, series design techniques were employed to insure an adequate spread of physicochemical ...
