Mannich bases of 4-phenyl-3-buten-2-one. A new class of antiherpes agent

ML Edwards, HW Ritter, DM Stemerick…

Index: Edwards, M.L.; Ritter, H.W.; Stemerick, D.M.; Stewart, K.T. Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 431 - 436

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Citation Number: 35

Abstract

The morpholine Mannich base of 4-phenyl-3-buten-2-one was found to have activity in model infections of herpes simplex. The activity was essentially equivalent to that of disodium phosphonoacetate. This paper presents the biological activity and synthesis of a series of derivatives and analogues of the lead compound.

~61%

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