The syntheses of the stereospecific deuteriated derivatives (2S, 4R)-and (2S, 4S)-[4-* H] homoserine lactone hydrochlorides,(2S, 3R)-[3-'H]-and (2S, 3S)-[2, 3-2Hz] homoserine lactone hydrochlorides, and (2S, 3R, 4Z3)-[3, 4-2H2]-and (2S, 3S, 4S)-[2, 3, 4-* H,] homoserine lactone hydrochlorides as well as the homoserine derivatives themselves have been synthesized in eight simple steps from the appropriate aspartic acids via a route ...