Tetrahedron letters

The absolute configuration and total synthesis of korormicin

H Uehara, T Oishi, K Yoshikawa, K Mochida…

Index: Uehara, Hisatoshi; Oishi, Tohru; Yoshikawa, Kazuhiro; Mochida, Kenichi; Hirama, Masahiro Tetrahedron Letters, 1999 , vol. 40, # 49 p. 8641 - 8645

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Citation Number: 19

Abstract

The marine antibiotic korormicin, isolated from the culture filtrate of marine bacterial strain Pseudoalteromonas sp. F-420, specifically inhibits the growth of marine Gram-negative bacteria without affecting terrestrial species. The absolute configuration of korormicin was determined by the combination of a CD exciton chirality method and chemical degradation. Convergent total synthesis of koromicin has been also achieved.