Synthesis and antifungal activity of novel thiazole-containing triazole antifungals. II. Optically active ER-30346 and its derivatives.

A Tsuruoka, Y Kaku, H Kakinuma, I TSUKADA…

Index: Chemical and Pharmaceutical Bulletin, , vol. 46, # 4 p. 623 - 630

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Citation Number: 31

Abstract

... Chemistry In order to construct a thiazole or benzo- thiazole moiety in the general formula 3, a cyano, thio- amide or formyl substituent is ... C) 1998 Pharmaceutical Society of ... and chemical shifts are expressed in ppm downficld from tetramethylsilane (TMS) as an internal reference ...

 Related Synthetic Route
P-CYANOACETOPHENONE Structure

1443-80-7

P-CYANOACETOPHENONE

~%

Ravuconazole Structure

182760-06-1

Ravuconazole

(αS,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-methyl-1H-1,2,4-triazole-1-butanenitrile Structure

170862-36-9

(αS,βR)-β-(2,4-...

~%

Ravuconazole Structure

182760-06-1

Ravuconazole

2-amino-1,3-benzothiazole-6-carbonitrile Structure

19759-66-1

2-amino-1,3-ben...

~52%

6-Cyanobenzothiazole Structure

58249-61-9

6-Cyanobenzothiazole

4-Aminobenzonitrile Structure

873-74-5

4-Aminobenzonitrile

~%

6-Cyanobenzothiazole Structure

58249-61-9

6-Cyanobenzothiazole


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