Abstract Structural prerequisites for the stability of the 3 1 helix of β-peptides can be defined from inspection of models (Figs. 1 and 2): lateral non-H-substituents in 2-and 3-position on the 3-amino-acid residues of the helix are allowed, axial ones are forbidden. To be able to test this prediction, we synthesized a series of heptapeptide derivatives Boc-(β-HVal-β-HAla- β-HLeu-Xaa-β-HVal-β-HAla-β-HLeu)-OMe 13–22 (Xaa= α-or β-amino-acid residue) and a ...
[Fisher, Liesl G.; Sher, Philip M.; Skwish, Stephen; Michel, Inge M.; Seiler, Steven M.; Dickinson, Kenneth E. J. Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 19 p. 2253 - 2258]
