Synthetic Communications®

Method for Regio-and Stereoselective Synthesis of (E)-β, γ-Unsaturated Acids from Aldehydes Under Solvent-Free Conditions

SJ Zhang, WX Hu

Index: Zhang, Shi-Jie; Hu, Wei-Xiao Synthetic Communications, 2010 , vol. 40, # 20 p. 3093 - 3100

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Citation Number: 2

Abstract

Synthesis of (E)-β, γ-unsaturated acids from aldehydes with malonic acid has been explored under solvent-free conditions. The modified Knoevenagel condensation reaction with N- methyl morpholine (NMM) as catalyst exhibits highly β, γ-regioselectivity and exclusively E-