A new methodology for the asymmetric synthesis of quaternary α-substituted amino acids using memory of chirality has been developed. The strategy utilizes the dynamic axial chirality of tertiary aromatic amides to memorize the initial chirality of an α-amino acid during an enolization step. Starting from five different l-amino acids, the corresponding oxazolidin-5- ones containing a tertiary aromatic amide group have been synthesized in one step and ...
