Ruthenium-Catalyzed Enantioselective Hydrogenation of Aryl-Pyridyl Ketones

…, X Xie, T Ayad, V Ratovelomanana-Vidal…

Index: Tao, Xiaoming; Li, Wanfang; Ma, Xin; Li, Xiaoming; Fan, Weizheng; Xie, Xiaomin; Ayad, Tahar; Ratovelomanana-Vidal, Virginie; Zhang, Zhaoguo Journal of Organic Chemistry, 2012 , vol. 77, # 1 p. 612 - 616

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Citation Number: 24

Abstract

Various substituted aryl-pyridyl ketones were hydrogenated in the presence of Ru- XylSunPhos-Daipen bifunctional catalytic system with enantiomeric excesses up to 99.5%. Upon introduction of a readily removable ortho-bromo atom to the phenyl ring, enantiomerically enriched 4-chlorophenylpyridylmethanol was obtained by hydrogenation method with 97.3% ee, which provided an important chiral intermediate for some ...