Enzymatic Conversion of Unnatural Amino Acids by Yeast D??Amino Acid Oxidase

A Caligiuri, P D'Arrigo, E Rosini…

Index: Caligiuri, Antonio; D'Arrigo, Paola; Rosini, Elena; Tessaro, Davide; Molla, Gianluca; Servi, Stefano; Pollegioni, Loredano Advanced Synthesis and Catalysis, 2006 , vol. 348, # 15 p. 2183 - 2190

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Citation Number: 42

Abstract

Abstract Unnatural amino acids, particularly synthetic α-amino acids, are becoming crucial tools for modern drug discovery research. In particular, this application requires enantiomerically pure isomers. In this work we report on the resolution of racemic mixtures of the amino acids d, l-naphthylalanine and d, l-naphthylglycine by using a natural enzyme, D- amino acid oxidase from the yeast Rhodotorula gracilis. A significant improvement of the ...

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