An Improved Large Scale Synthesis of the Schöllkopf Chiral Auxiliaries:(2 R)-and (2 S)-2, 5-Dihydro-3, 6-dimethoxy-2-isopropylpyrazine

J Chen, SP Corbin, NJ Holman

Index: Organic Process Research and Development, , vol. 9, # 2 p. 185 - 187

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Citation Number: 25

Abstract

... Organic Process Research & Development. ... The workup of this reaction was improved by the use of aqueous sodium hydroxide to adjust the pH to 8−9 rather than using sodium bicarbonate as in the original procedure; the latter ... The process is easy to execute and scale-up. ...