Synthesis of salicylaldehydes bearing bulky substituents in the positions 3 and 5

AI Kochnev, II Oleynik, IV Oleynik, SS Ivanchev…

Index: Kochnev; Oleynik; Ivanchev; Tolstikov Russian Chemical Bulletin, 2007 , vol. 56, # 6 p. 1125 - 1129

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Citation Number: 17

Abstract

Abstract Reaction of 2, 4-disubstituted phenols with paraformaldehyde in the presence of SnCl 4 and 2, 6-lutidine afforded a number of new salicylaldehydes, containing bulky substituents (tert-butyl, 1-phenylethyl, 1-(4-tert-butylphenyl) ethyl, α-cumyl, and trityl) in the positions 3 and 5.

 Related Synthetic Route
phenylene-ethylene Structure

292638-84-7

phenylene-ethylene

Phenol Structure

108-95-2

Phenol

~82%

2-(1-Phenylethyl)phenol Structure

4237-44-9

2-(1-Phenylethy...

α-methylstyrene Structure

98-83-9

α-methylstyrene

Phenol Structure

108-95-2

Phenol

~52%

2,4-Bis(α,α-diMethylbenzyl)phenol Structure

2772-45-4

2,4-Bis(α,α-diM...

2-(2-phenylpropan-2-yl)phenol Structure

18168-40-6

2-(2-phenylprop...

2-tert-Butylphenol Structure

88-18-6

2-tert-Butylphenol

α-methylstyrene Structure

98-83-9

α-methylstyrene

~88%

2-(1,1-dimethylethyl)-4-(1-methyl-1-phenylethyl)phenol Structure

56187-92-9

2-(1,1-dimethyl...

α-methylstyrene Structure

98-83-9

α-methylstyrene

Phenol Structure

108-95-2

Phenol

~36%

2,4-Bis(α,α-diMethylbenzyl)phenol Structure

2772-45-4

2,4-Bis(α,α-diM...

2-(2-phenylpropan-2-yl)phenol Structure

18168-40-6

2-(2-phenylprop...

4-tert-Butylphenol Structure

98-54-4

4-tert-Butylphenol

α-methylstyrene Structure

98-83-9

α-methylstyrene

~75%

4-tert-butyl-2-(2-phenylpropan-2-yl)phenol Structure

52938-75-7

4-tert-butyl-2-...


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