New synthesis of (±)-α-CMBHC and its confirmation as a metabolite of α-tocopherol (vitamin E)

…, GE Burtin, PT Clayton, DJ Madge, DPR Muller

Index: Pope, Simon A.S.; Burtin, Guillaume E.; Clayton, Peter T.; Madge, David J.; Muller, David P.R. Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 5 p. 1337 - 1343

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Citation Number: 21

Abstract

There is currently interest in the metabolism of the various compounds which make up the vitamin E family, especially with regards to the possible use of vitamin E metabolites as markers of oxidative stress and adequate vitamin E supply. A number of vitamin E metabolites have been described to date and we have recently developed a method to extract and quantitate a range of vitamin E metabolites in human urine. During the ...