e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Hypoxia-selective agents derived from quinoxaline 1, 4-di-N-oxides

…, JA Palop, AL de Cerain, V Senador…

Index: Monge, Antonio; Palop, Juan A.; Cerain, Adela Lopez de; Senador, Virginia; Martinez-Crespo, Francisko J.; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1786 - 1792

Full Text: HTML

Citation Number: 134

Abstract

Hypoxic cells, which are a common feature of solid tumors, but not normal tissues, are resistant to both anticancer drugs and radiation therapy. Thus the identification of drugs with selective toxicity toward hypoxic cells is an important objective in anticancer chemotherapy. The benzotriazine di-N-oxide (SR 4233, Tirapazamine) has been shown to be an efficient and selective cytotoxin for hypoxic cells. Since the bioreductive activation of Tirapazamine ...

p-Anisidine Structure

~%

Benzenamine,4-methoxy-2,6-dinitro- Structure

Benzenamine,4-m...

4-METHOXY-2-NITROACETANILIDE Structure

4-METHOXY-2-NIT...

~%

Benzenamine,4-methoxy-2,6-dinitro- Structure

Benzenamine,4-m...

4'-Methoxyacetanilide Structure

4'-Methoxyaceta...

~%

Benzenamine,4-methoxy-2,6-dinitro- Structure

Benzenamine,4-m...

ethyl 4-acetamido-3-nitrobenzoate Structure

ethyl 4-acetami...

~%

ethyl 4-amino-3-nitrobenzoate Structure

ethyl 4-amino-3...

3,4-Difluoroaniline Structure

3,4-Difluoroaniline

~%

ETHYL2-CHLORO-5-NITROBENZOATE Structure

ETHYL2-CHLORO-5...

2'-Nitroacetanilide Structure

2'-Nitroacetanilide

~%

Benzofuroxan Structure

Acetanilide Structure

~%

Benzofuroxan Structure

4'-fluoro-2'-nitroacetanilide Structure

4'-fluoro-2'-ni...

~%

4-FLUORO-3-NITROPHENYL AZIDE Structure

4-FLUORO-3-NITR...

2,1,3-Benzoxadiazole,5-methyl-, 1-oxide Structure

2,1,3-Benzoxadi...

Malononitrile Structure

~%

4-hydroxy-3-imino-6-methyl-1-oxido-quinoxaline-2-carbonitrile Structure

4-hydroxy-3-imi...

3-amino-7-methyl-2-quinoxalinecarbonitrile 1,4-di-N-oxide Structure

3-amino-7-methy...

2-Nitro-p-acetotoluidide Structure

2-Nitro-p-aceto...

~%

4-hydroxy-3-imino-6-methyl-1-oxido-quinoxaline-2-carbonitrile Structure

4-hydroxy-3-imi...

3-Nitro-4-azidotoluene Structure

3-Nitro-4-azido...

~%

4-hydroxy-3-imino-6-methyl-1-oxido-quinoxaline-2-carbonitrile Structure

4-hydroxy-3-imi...

p-Toluidine Structure

~%

4-hydroxy-3-imino-6-methyl-1-oxido-quinoxaline-2-carbonitrile Structure

4-hydroxy-3-imi...

4'-Methylacetanilide Structure

4'-Methylacetanilide

~%

4-hydroxy-3-imino-6-methyl-1-oxido-quinoxaline-2-carbonitrile Structure

4-hydroxy-3-imi...

1-Amino-2-nitro-4-methylbenzene Structure

1-Amino-2-nitro...

~%

4-hydroxy-3-imino-6-methyl-1-oxido-quinoxaline-2-carbonitrile Structure

4-hydroxy-3-imi...

2'-Nitroacetanilide Structure

2'-Nitroacetanilide

~%

Benzene,1-azido-2-nitro- Structure

Benzene,1-azido...

Acetanilide Structure

~%

Benzene,1-azido-2-nitro- Structure

Benzene,1-azido...

4',5'-Dimethyl-2'-nitroacetanilide Structure

4',5'-Dimethyl-...

~%

3,4-dimethyl-9-oxido-8-oxa-7-aza-9-azoniabicyclo[4.3.0]nona-2,4,6,9-tetraene Structure

3,4-dimethyl-9-...

3',4'-dimethylacetanilide Structure

3',4'-dimethyla...

~%

3,4-dimethyl-9-oxido-8-oxa-7-aza-9-azoniabicyclo[4.3.0]nona-2,4,6,9-tetraene Structure

3,4-dimethyl-9-...

3,4-Dimethylaniline Structure

3,4-Dimethylaniline

~%

3,4-dimethyl-9-oxido-8-oxa-7-aza-9-azoniabicyclo[4.3.0]nona-2,4,6,9-tetraene Structure

3,4-dimethyl-9-...

1-azido-4,5-dimethyl-2-nitrobenzene Structure

1-azido-4,5-dim...

~%

3,4-dimethyl-9-oxido-8-oxa-7-aza-9-azoniabicyclo[4.3.0]nona-2,4,6,9-tetraene Structure

3,4-dimethyl-9-...

N-(4-chloro-5-fluoro-2-nitrophenyl)acetamide Structure

N-(4-chloro-5-f...

~%

4-Chloro-5-fluoro-2-nitroaniline Structure

4-Chloro-5-fluo...

acetic acid-(4-chloro-3-fluoro-anilide) Structure

acetic acid-(4-...

~%

4-Chloro-5-fluoro-2-nitroaniline Structure

4-Chloro-5-fluo...

4-Aminobenzotrifluoride Structure

4-Aminobenzotri...

~%

N-[2-Nitro-4-(trifluoromethyl)phenyl]acetamide Structure

N-[2-Nitro-4-(t...

3,4-Difluoroaniline Structure

3,4-Difluoroaniline

~%

5,6-Difluoro-2,1,3-benzoxadiazole 1-oxide Structure

5,6-Difluoro-2,...

ETHYL2-CHLORO-5-NITROBENZOATE Structure

ETHYL2-CHLORO-5...

~%

5,6-Difluoro-2,1,3-benzoxadiazole 1-oxide Structure

5,6-Difluoro-2,...

Acetamide,N-(3,4-difluorophenyl)- Structure

Acetamide,N-(3,...

~%

5,6-Difluoro-2,1,3-benzoxadiazole 1-oxide Structure

5,6-Difluoro-2,...

4'-Nitro-4-biphenylamine Structure

4'-Nitro-4-biph...

Ethanoic anhydride Structure

Ethanoic anhydride

~%

4-nitro-4'-(acetylamino)biphenyl Structure

4-nitro-4'-(ace...

p-Phenylenediamine Structure

p-Phenylenediamine

~%

1,4-Diacetamino-2-nitrobenzene Structure

1,4-Diacetamino...

4'-Aminoacetanilide Structure

4'-Aminoacetanilide

~%

1,4-Diacetamino-2-nitrobenzene Structure

1,4-Diacetamino...

4-Fluoroaniline Structure

4-Fluoroaniline

~%

5-fluorobenzofuroxan Structure

5-fluorobenzofuroxan

4-FLUORO-3-NITROPHENYL AZIDE Structure

4-FLUORO-3-NITR...

~%

5-fluorobenzofuroxan Structure

5-fluorobenzofuroxan

N-(4-Chloro-2-nitrophenyl)acetamide Structure

N-(4-Chloro-2-n...

~%

2,1,3-Benzoxadiazole,5-chloro-, 1-oxide Structure

2,1,3-Benzoxadi...

4-Chloroaniline Structure

4-Chloroaniline

~%

2,1,3-Benzoxadiazole,5-chloro-, 1-oxide Structure

2,1,3-Benzoxadi...

4-Chloroacetanilide Structure

4-Chloroacetanilide

~%

2,1,3-Benzoxadiazole,5-chloro-, 1-oxide Structure

2,1,3-Benzoxadi...

p-Toluidine Structure

~%

3-Nitro-4-azidotoluene Structure

3-Nitro-4-azido...

1-Amino-2-nitro-4-methylbenzene Structure

1-Amino-2-nitro...

~%

3-Nitro-4-azidotoluene Structure

3-Nitro-4-azido...

2-Nitro-p-acetotoluidide Structure

2-Nitro-p-aceto...

~%

3-Nitro-4-azidotoluene Structure

3-Nitro-4-azido...

4'-Methylacetanilide Structure

4'-Methylacetanilide

~%

3-Nitro-4-azidotoluene Structure

3-Nitro-4-azido...

Revised Students' Check-List of Texts Illustrating the Histo...

[Reverdin Chemische Berichte, 1909 , vol. 42, p. 1526 Chem. Zentralbl., 1909 , vol. 80, # I p. 1810]

Structural and Electrochemical Studies of Co (III) Cage Amin...

[Galliani, Guido; Rindone, Bruno Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 828 - 832]

Structural and Electrochemical Studies of Co (III) Cage Amin...

[Galliani, Guido; Rindone, Bruno Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 828 - 832]

Structural and Electrochemical Studies of Co (III) Cage Amin...

[Galliani, Guido; Rindone, Bruno Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 828 - 832]

Structural and Electrochemical Studies of Co (III) Cage Amin...

[Galliani, Guido; Rindone, Bruno Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 828 - 832]